منابع مشابه
Clearing Factor, a Heparin-activated Lipoprotein Lipase
In the first paper of this series (l), evidence was presented which demonstrates that the clearing factor which appears in postheparin plasma is present in the hearts of normal, non-heparinized rats. This strongly supports the view that the enzyme functions in normal fat metabolism. In this paper, the substrate specificity of lipoprotein lipase is defined, the conversion of coconut oil into an ...
متن کاملPlasma lipoprotein lipase after subcutaneous heparin.
IN ADDITION to its anticoagulant action, heparin initiates the release of lipoprotein lipase into the blood. This lipolytic enzyme has the capacity to reduce the turbidity of lipemic plasma and hence has become known also as "clearing factor." Its clearing action occurs from the hydrolysis of triglyceride contained in chylomicrons and other lipoprotein particles.' Studies in animals have sugges...
متن کاملDepletion of lipoprotein lipase after heparin administration.
Some or most of the turnover of lipoprotein lipase (LPL) occurs by dissociation from vascular endothelial sites in extrahepatic tissues and further degradation in the liver. Heparin greatly enhances this dissociation and delays but does not abolish uptake in the liver, raising the possibility that heparin could lead to accelerated catabolism of functional LPL. To investigate this, we determined...
متن کاملEffects of heparin on lipoprotein lipase from bovine milk.
The effect of heparin on the activity of lipoprotein lipase from bovine milk was investigated under conditions varying with regard to ionic strength, purity of enzyme, and mode of substrate activation. A crude enzyme (dialyzed skim milk) was studied, along with a purified preparation obtained by affinity chromatography on a column of heparin-substituted agarose. Serum, high density lipoproteins...
متن کاملThe metabolic "switch" AMPK regulates cardiac heparin-releasable lipoprotein lipase.
The "fuel gauge" AMP-activated protein kinase (AMPK) facilitates ATP production to meet energy demands during metabolic stress. Given the importance of lipoprotein lipase (LPL) in providing hearts with fatty acids (FA), the preferred substrate consumed by the heart, the objective of the present study was to investigate whether activation of AMPK influences LPL at its functionally relevant locat...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2004
ISSN: 1880-3873,1340-3478
DOI: 10.5551/jat.11.1